紫杉醇脂质体与传统紫杉醇治疗乳腺癌的临床对比分析

Clinical Comparative Analysis of Paclitaxel Liposome and Traditional Paclitaxel in the Treatment of Breast Cancer

目的:探讨紫杉醇脂质体与传统紫杉醇治疗乳腺癌的临床疗效。方法:选取江西省妇幼保健院在2011年10月~2016年10月期间诊治的乳腺癌患者184例,采用数字随机法分为两组,对照组患者92例采用传统紫杉醇治疗,观察组患者92例采用紫杉醇脂质体治疗,于治疗前后行疼痛、心理状况、生活质量评定,比较两组患者的临床疗效及安全性。结果:治疗后,两组患者疼痛评分、SAS评分、SDS评分降低(P<0.05)。两组患者生活质量评分增加(P<0.05)。观察组患者疼痛评分、SAS评分、SDS评分低于对照组(P<0.05)。观察组患者生活质量评分高于对照组(P<0.05)。观察组患者临床疗效好于对照组(P<0.05)。观察组患者不良反应(白细胞减少、恶心呕吐、胃肠道反应、脱发、过敏反应、肌肉痛)发生率低于对照组(P<0.05)。结论:紫杉醇脂质体与传统紫杉醇均可用于乳腺癌的临床治疗,但紫杉醇脂质体的效果更佳。

Objective： To investigate clinical effect of paclitaxel liposome and traditional paclitaxel in the treatment of breast cancer. Methods： 184 patients with breast cancer selected in hospital from October 2011 to October 2016 were divided into two groups by digital random method. 92 patients were treated traditional paclitaxel as control group. 92 patients were treated paclitaxel liposome as observation group. Pain, psychological status, quality of life was evaluated before and after treatment. Clinical efficacy and safety were compared between two groups. Results： Pain score,SAS score, SDS score decreased in two groups after treatment（P0.05）. Quality of life score increased in two groups after treatment（P0.05）. Pain score,SAS score, SDS score in observation group were lower than control group（P0.05）. Quality of life score in observation group was higher than control group（P0.05）. Clinical effect in observation group was better than control group（P0.05）. Incidence of adverse reactions（white blood cell reduction, nausea and vomiting, gastrointestinal reactions, alopecia, anaphylaxis, muscle pain） in observation group was lower than control group（P0.05）. Conclusion： Paclitaxel liposome and traditional paclitaxel can be used in clinical treatment of breast cancer, while paclitaxel liposome is better.