GLP-1对2型糖尿病患者心肌及血管舒张功能的影响

Effects of GLP-1 on cardiac function and vasodilation function in patients with type 2 diabetes mellitus

目的探讨胰高血糖素样肽-1(GLP-1)对2型糖尿病患者心肌及血管舒张功能的影响。方法选取96例2型糖尿病患者为研究对象,应用随机数字表法分成观察组(n=48)和对照组(n=48),其中观察组采用二甲双胍+GLP-1方案,对照组采用二甲双胍+胰岛素方案。比较治疗前后血脂指标[甘油三酯(TG)、总胆固醇(TC)]、心功能指标[左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)]及肱动脉血管舒张率。结果治疗后,两组受试者TG、TC水平均较治疗前显著降低,且观察组优于对照组(P<0.05);两组LVEF水平及肱动脉血管舒张率较治疗前显著提高,且观察组优于对照组(P<0.05);两组LVEDD水平同治疗前比较,差异无统计学意义(P>0.05)。结论 GLP-1对2型糖尿病患者心血管系统具有一定保护作用,对预后恢复有利。

Objective To investigate the effects of glucagon like peptide-1( GLP-1) on cardiac function and vasodilation function in patients with type 2 diabetes mellitus. Methods 96 patients with type 2 diabetes mellitus were selected as study subjects and divided into observation group( n = 48) and control group( n = 48) by a random number table. The observation group was treated with metformin and GLP-1 while the control group was treated with metformin and insulin. Before and after treatment,the blood lipid indexes [triglyceride( TG),total cholesterol( TC) ],cardiac function indexes [left ventricular end diastolic diameter( LVEDD),left ventricular ejection fraction( LVEF) ] and brachial artery vasodilation rate were compared.Results After treatment,the levels of TC and TG in the two groups were significantly lower than those before treatment,and the observation group was better than the control group( P < 0. 05); LVEF levels and brachial artery bvasodilation rates after treatment were significantly higher than those before treatment,and the observation group was better than the control group( P <0. 05); There was no significant difference between the two groups in LVEDD before treatment( P > 0. 05).Conclusion GLP-1 has certain protective effect on the cardiovascular system of patients with type 2 diabetes mellitus and it is beneficial to the prognosis.