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强化降脂治疗对急性冠脉综合征患者经皮冠状动脉介入效果的影响 被引量:2

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摘要 目的研究强化降脂治疗对急性冠脉综合征患者经皮冠状动脉介入效果的影响。方法选择河南煤化鹤壁煤业集团总医院2013年1月至2016年1月收治的110例急性冠脉综合症患者作为研究对象。将所有患者随机分为对照组和观察组,各55例。两组患者均接受经皮冠状动脉介入治疗,观察组采用40 mg辛伐他汀+氯吡格雷+阿司匹林+硝酸酯类药物,对照组采用10 mg辛伐他汀+氯吡格雷+阿司匹林+硝酸酯类药物,对比观察两组患者置入支架后即刻心肌灌注情况以及治疗前后血清ICAM-1、hs-CPR和P选择素水平。结果观察组在置入支架后TIMI血流0、1级者少于对照组,TIMI血流3级者显著多于对照组,差异有统计学意义(P<0.05);观察组TMPG3级和无复流发生情况优于对照组,差异有统计学意义(P<0.05)。治疗前两组患者血清ICAM-1、hs-CPR和P选择素水平比较,差异无统计学意义(P>0.05);经过治疗后观察组血清ICAM-1、hs-CPR和P选择素水平显著低于对照组,差异有统计学意义(P<0.05)。结论在急性冠脉综合症患者接受经皮冠状动脉介入治疗前使用强化他汀类药物,能够显著提高治疗效果,控制心肌损伤,具有较高的临床价值。
作者 李华政
出处 《河南医学研究》 CAS 2017年第2期239-240,共2页 Henan Medical Research
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