炎性细胞因子与新生血管性眼病

Inflammatory cytokines in neovascular eye diseases

新生血管性眼病是引起人类不可逆视力损害的主要病因。尽管眼内抗血管内皮生长因子药物治疗已成为临床中新生血管性眼病的重要疗法之一,但该疗法本身疗效不稳定且存在诸多的潜在风险和并发症。因此探寻更明确有效的治疗靶点是必要的。研究表明,肿瘤坏死因子-α、白细胞介素-1、白细胞介素-6和白细胞介素-18等炎性细胞因子与新生血管性眼病关系密切,本文就近些年来与新生血管性眼病相关的炎性细胞因子作一综述。

Neovascular eye diseases are the leading cause of irreversible visual impairment in humans.Although intraocular anti-vascular endothelial growth factor therapy has become one of the most important treatments for these disease,the treatment itself is not stable and there are many potential risks and complications.So it is necessary to explore a clearer and more effective therapeutic target.Studies have shown that the inflammatory cytokines,especially TNF-α,IL^-1,IL-6 and IL^-18,are closely related to the onset of neovascular eye diseases.Therefore,a review on inflammatory cytokines in neovascular eye diseases will present in this article.