认知障碍简明评价表对帕金森病患者轻度认知功能障碍的诊断价值

Diagnostic value of cognitive-12 scale on mild cognitive impairment in Parkinson's disease patients

目的探讨认知障碍简明评价表(Cog-12量表)对帕金森病(PD)患者轻度认知功能障碍的诊断价值。方法将85例PD患者按认知障碍诊断标准分为认知功能正常组(45例)、轻度认知功能障碍组(PD-MCI)组(40例)。采用Cog-12量表、蒙特利尔认知评估量表(MoCA)及MMSE量表对患者进行测评,分析3个量表对PD患者轻度认知障碍的筛查能力。结果与认知功能正常组比较,PD-MCI组Cog-12量表评分显著升高,MoCA、MMSE量表评分显著降低(均P<0.001)。Cog-12对PD患者MCI的鉴别能力明显优于MoCA、MMSE(AUC_(Cog-12)=0.958,敏感度为85.7%,特异度为75%;AUC_(MMSE)=0.798,敏感度为52.4%,特异度为26.5%;AUC_(MoCA)=0.907,敏感度为71.4%,特异度为21.5%)。当Cog-12界值为7.5分时,其敏感性为85.7%。结论 Cog-12量表可有效检测PD患者的认知功能损伤,可应用于临床PD患者认知功能的筛查。

Objective To explore the diagnostic value of cognitive-12 scale（ Cog-12 scale） on mild cognitive impairment（ MCI） in Parkinson＇s disease（ PD）. Methods Eighty-five PD patients were divided into normal cognitive function group（ 45 cases） and mild cognitive impairment（ PD-MCI） group（ 40 cases） by cognitive disorder diagnostic criteria. Cog-12 scale,Montreal cognitive assessment scale（ MoCA）,MMSE weight tables for patient evaluation,analysis of them on PD patients with mild cognitive impairment screen. Results Compared with normal cognitive function group,the score of Cog-12 scale was significantly increased,scores of MoCA and MMSE were significantly decreased（ all P〈0. 001）. The discriminating ability of Cog-12 diagnosed MCI in PD patients was better than MoCA and MMSE（ AUCCog-12= 0. 958,sensitivity was 85. 7%,specificity was 75%; AUCMMSE= 0. 798,sensitivity was 52. 4%,specificity was 26. 5%; AUCMoCA= 0. 907,sensitivity was 71. 4%, specificity was21. 5%）. The area under ROC curve showed that the sensitivity of Cog-12 score in predicting MCI was 85. 7% when its cutoff value was 7. 5. Conclusions Cog-12 scale can be effective in detecting cognitive impairment in patients with PD. It can be applied to clinical screening for cognitive dysfunction in PD patients.