SPARC在胃癌发生机制中作用的研究进展

Research Progress on SPARC in Pathogenesis of Gastric Cancer

富含半胱氨酸的酸性分泌蛋白(secreted protein,acidic and rich in cysteine,SPARC)作为一种细胞外基质糖蛋白,能够调节细胞和基质之间的相互作用,与多种恶性肿瘤的发生发展相关,且具有组织特异性。SPARC在胃癌组织中的表达,高于正常胃黏膜组织且主要定位于胃癌间质细胞;而在大多数胃癌细胞系中,内源性SPARC呈现表达抑制或缺失状态。SPARC对胃癌的侵袭、转移、血管新生等存在负性调节的作用,而对于增殖的影响目前尚无一致性结论。此外,SPARC启动子Cp G岛甲基化在胃癌中较普遍。本文对SPARC在胃癌多种生物学行为方面的作用机制进行综述,旨在总结SPARC在胃癌发生发展中的作用,为胃癌早期诊断和靶向治疗提供新思路。

As one of extracellular glycoproteins, secreted protein, acidic and rich in cysteine （SPARC） can regulate the interaction between cells and matrix. SPARC, which is tissuespecific plays an important role in the development of many malignant neoplasms, which is tissue-specific. In gastric tissues, SPARC is expressed in carcinoma tissues at a higher level compared with normal mucosa tissues, and mainly located at stromal cells; while in most gastric cancer cells, endogenous SPARC expression is at a low level or even absent. SPARC may negatively modulate several biological behaviors of gastric cancer, such as invasion, metastasis and angiogenesis, but the effect on the proliferation is still controversial. The methylation of SPARC promoter commonly exists in gastric cancer. This review aims to summarize the mechanism of interaction between SPARC and gastric cancer and to explore a new way to early diagnose and treat gastric cancer timely.