摘要
目的 探讨马来酸曲美布汀联合香砂平胃颗粒治疗功能性消化不良的临床效果以及对胃肠激素的影响.方法 120例功能性消化不良患者应用随机数字表分为对照组和观察组,每组60例.对照组给予马来酸曲美布汀口服,0.2 g,3次/d;观察组在对照组的基础上加用香砂平胃颗粒口服,10 g,2次/d.两组均4周为1个疗程.比较两组患者的临床疗效以及对胃肠激素水平的影响.结果 两组患者治疗后症状积分均显著下降,观察组餐后饱胀,早饱,上腹痛积分显著低于对照组t值分别为34.36、27.62、33.87,P〈0.05).观察组总有效率90.00%(54/60)显著高于对照组73.33%(44/60),差异有统计学意义(χ2=5.57,P〈0.05).两组患者治疗后胃动素(MOT)和促胃激素(GAS)水平均显著升高,观察组MOT和GAS水平均显著高于对照组MOT:(355.2±78.1) ng/L与(288.7±82.4) ng/L;GAS:(96.5±17.6) ng/L与(88.4±16.0) ng/L,t值分别为4.54、2.64,P〈0.05;两组患者治疗后生长抑素(SS)水平均显著下降,观察组SS水平显著低于对照组(41.1±11.1) ng/L与(48.9±12.9) ng/L,t=3.55,P〈0.05.结论 马来酸曲美布汀联合香砂平胃颗粒可明显改善功能性消化不良患者的临床症状和胃肠激素水平.
Objective To investigate the clinical efficacy of trimebutine combined with Xiangsha Pingwei in the treatment of functional dyspepsia and its effect on gastrointestinal hormone.Methods One hundred and twenty cases of functional dyspepsia were randomly divided into the control group and observation group,60 cases in each group.The control group was treated with trimebutine 0.2 g,3 times/d and the observation group was treated with trimebutine 0.2 g,3 times/d and Xiangsha Pingwei 10 g,2 times/d.Both groups were treated for four weeks,a course of treatment.Clinical efficacy and the influence on gastrointestinal hormone levels were compared between the two groups.Results The symptoms scores in both groups all decreased significantly after treatment.While the postprandial fullness scores,early satiety scores and epigastric pain scores in the observation group were significantly lower than those in the control group (0.62±0.12 vs.1.85±0.25,0.56±0.14 vs.1.46±0.21,0.48±0.15 vs.1.32±0.12,t=34.36,27.62,33.87,P〈0.05).The total effective rate in the observation group was significantly higher than that in the control group (90.00% vs.73.33%,χ2=5.57,P〈0.05).MOT and GAS levels in both groups increased significantly.While MOT and GAS levels in the observation group were significantly higher than those in the control group (MOT: (355.2±78.1) ng/L vs.(288.7±82.4) ng/L;GAS:(96.5±17.6) ng/L vs.(88.4±16.0) ng/L,t=4.54,2.64,P〈0.05).The somatostatin (SS) level in both groups decreased significantly.While the SS level in the observation group was significantly lower than that in the control group ((41.1±11.1) ng/L vs.(48.9±12.9) ng/L,t=3.55,P〈0.05).Conclusion Trimebutine combined with Xiangsha Pingwei can significantly improve the clinical symptoms and gastrointestinal hormone in patients with functional dyspepsia.
作者
于惠玲
鲁素彩
常颖
尹玲
张玉梅
王雅清
张京
王小叶
Yu Huiling Lu Sucai Chang Ying Yin Ling Zhang Yumei Wang Yaqing Zhang Jing Wang Xiaoye(Department of Gastroenterology, Affiliated Hospital of Hebei University, Baoding 071000, China)
出处
《中国综合临床》
2017年第8期690-694,共5页
Clinical Medicine of China
基金
河北省中医药管理局科研计划课题(2014197)
河北省保定市科学技术研究与发展指导计划项目(16ZF029)