乌司他丁对低血容量性休克疗效的Meta分析

Meta analysis about effect of ulinastatin on hypovolemic shock

目的:研究乌司他丁对低血容量性休克的疗效。方法:检索Pubmed、Embase、万方、中国知网等数据库,获得乌司他丁对低血容量性休克疗效的RCT及随机对照试验,以治疗后第1天的肝肾功为疗效判定指标。采用Revman 5.3及StataSE 12.0软件进行分析,计量资料选择WMD或者SMD及其95%CI表示。结果:(1)共纳入13篇文献,质量中等偏下;(2)Meta分析显示,乌司他丁组与对照组第1天ALT、肌酐差异有统计学意义。结论:对于低血容量性休克,早期使用乌司他丁可改善肝肾功能。研究间有异质性,故结果需谨慎对待。

Objective：In order to explore the efficacy of ulinastatin on hypovolemic shock. Method：A liturature retrieval was performed among PubMed, EMBASE, Wangfang and VIP database. Randomized control trails were acquired about the effect of ulinastatin on hypovolemic shock patients. Liver, kidnney function of one day after treatment were measured as primary effect index. Revman 5.3 and StataSE 12.0 software were used for meta anal- ysis. Measurement data were expressed as WMD, SMD and its 95 % CI. Result ： ① Thirteen articles were retrieved into meta analysis. ②There was significant diffirenee of ALT, Set in the first day between ulinastatin group and control group. Conclusion：To hypovolemic shock, the early use of ulinastatin can improve liver function;but consid- ering heterogeneity among artieles,the result need be treated cautiously.