白细胞介素-37与自身免疫性疾病

interleukin-37 and autoimmune diseases

白细胞介素（interleukin，IL）-37是新近发现的IL-1家族细胞因子，对固有免疫和适应性免疫均有抑制作用。IL-37主要表达于中性粒细胞、淋巴细胞、巨噬细胞、单核细胞、组织上皮细胞、角质形成细胞和树突状细胞。最近大量研究显示，IL-37在许多自身免疫性疾病患者或动物模型中表达异常并发挥关键作用，如系统性红斑狼疮、炎症性肠病、强直性脊柱炎、支气管哮喘、银屑病、Graves病以及类风湿性关节炎等。深入研究IL-37的生物学功能、信号转导途径及作用机制将为IL-37在自身免疫性疾病的治疗提供新思路和靶点。

Interleukine（IL）-37,a new member of the IL-1 family,inhibits innate inflammation as well as acquired immune responses. IL-37 is mainly expressed on neutrophils, lymphocytes, maerophages, monocytes, epithelial cells, keratinocytes and dendritic cells. Recent studies have shown IL-37 plays a key role in autoim- mune diseases, such as systemic lupus erythematosus, inflammatory bowel disease, ankylosing spondylitis, asth- ma, psoriasis, Graves＇ disease and rheumatoid arthritis. We present the history and the biology of IL-37, and dis- cuss the role of IL-32 in several autoimmune diseases.