血清中促甲状腺激素和C-反应蛋白水平与高血压患者颈动脉病变及脑血管事件的相关性研究

Relationship of serum levels of thyroid stimulating hormone and C-reaction protein with carotid atherosclerosis and cerebrovascular events in patients with carotid artery disease

目的探讨高血压合并颈动脉粥样硬化患者血清中促甲状腺激素(TSH)和C-反应蛋白(CRP)水平与高血压患者颈动脉病变程度及脑血管事件发生的关系。方法选取本院2015年11月-2016年11月收治的85例高血压患者作为研究对象,检测患者血清中促甲状腺激素和CRP水平与患者颈动脉病变程度,采用Logistics回归分析探讨血清中TSH和CRP水平与患者脑血管事件发生的关系。结果低水平CRP、TSH组患者内-中膜厚度、斑块面积均低于相应高水平组患者,差异均有统计学意义(P<0.05)。低水平CRP、TSH组软斑块发生率低于对应高水平组患者,而硬斑块发病率高于对应高水平组患者,差异均有统计学意义(P<0.05)。Logistics回归分析结果提示,TSH、软斑块、CRP是患者脑血管事件的独立风险因素(P<0.05)。结论血清中TSH和CRP水平高的患者颈动脉病变越严重,脑血管事件风险更高。

Objective To investigate the relationship of the levels of thyroid stimulating hormone（ TSH） and C-reactive protein（ CRP） with the degree of carotid artery stenosis in patients with hypertension and cerebrovascular events in hypertensive patients with carotid atherosclerosis. Methods 85 cases of patients with hypertension were enrolled in our hospital from November 2015 to November 2016. The TSH and CRP levels were detected and compared in patients with carotid artery stenosis and carotid artery plaque types. The logistics regression analysis was used to explore the relationship of serum TSH and CRP levels with cerebrovascular events. Results The intima-media thickness and plaque area were significantly lower than that in the patients of high CRP level and high TSH level group,and the differences were statistically significant（ P〈0. 05）. The frequency of soft plaque in low CRP and low TSH group were significantly lower than the corresponding high level group,while that of hard plaque was higher than the high level group,with the differences statistically significant（ P〈0. 05）. TSH,soft plaque,CRP were the independent risk factors of cerebrovascular events in patients by logistics regression analysis. Conclusion The patients with high serum levels of TSH and CRP are related to the severe carotid lesions and high risk of cerebrovascular events.