多学科综合护理干预对消化性溃疡患者氧化应激和Th17/IL-17炎症轴的影响

Effects of multidisciplinary comprehensive nursing intervention on oxidative stress and Th17/IL-17 inflammation axis in patients with peptic ulcer

目的探讨多学科综合护理干预对消化性溃疡患者氧化应激和Th17/IL-17炎症轴的影响,为临床工作提供理论依据。方法选择2015年11月-2016年11月本院消化性溃疡患者92例作为研究对象,根据随机数字表法分为观察组和对照组,各46例,观察组患者采用多学科综合护理干预,对照组患者采用常规护理干预,探讨多学科综合护理干预在消化性溃疡患者中运用的效果及对患者氧化应激和Th17/IL-17水平的影响。结果治疗后MDA、AOPP均较治疗前下降,且观察组低于对照组患者;治疗后抗氧化物GSH-PX、SOD较前明显上升,且观察组高于对照组患者;治疗后观察组患者血清中IL-17、IL-21、TNF-α水平均低于对照组患者;治疗后观察组患者情绪角色、心理健康、疼痛、躯体角色、躯体功能、社会功能、活力、总健康评分均优于对照组,上述差异均有统计学意义(P<0.05)。结论多学科合作延续护理运用在消化性溃疡患者中有助于改善患者氧化应激和炎症状态,改善患者生存质量。

Objective To investigate the effect of multidisciplinary comprehensive nursing intervention on oxidative stress and inflammatory axis of Th17/IL-17 in patients with peptic ulcer,so as to provide theoretical basis for clinical work. Methods 92 cases of peptic ulcer during January 2015-January 2016 in our hospital were selected as the research objects,and randomly divided into the observation group and the control group,with 46 cases of each,while multidisciplinary comprehensive nursing intervention was used in the observation group,and routine nursing intervention was used in the control group,so as to explore the effect of multidisciplinary comprehensive nursing intervention on the oxidative stress and Th17/IL-17 levels. Results After treatment,MDA and AOPP were lower than that that before treatment,and that in the observation group was lower than that of the control group; after treatment,antioxidant GSH-PX and SOD significantly increased,and that in the observation group was higher than that of the control group; in the observation group after treatment,the levels of IL-17,IL-21,TNF-alpha were lower than those in the control group; the emotional role,mental health,pain,physical role,physical function,social function,vitality,general health scores in the observation group were better than the control group,and the differences were statistically significant（ P〈0. 05）. Conclusion Multidisciplinary cooperative continuing care helps to improve the oxidative stress and inflammatory status,so as to improve the life quality in patients with peptic ulcer.