延玉合剂治疗老年稳定劳力型心绞痛40例临床观察

Clinical efficacy of Yanyu mixture in elderly patients with stable exertional angina pectoris: an analysis of 40 cases

目的:探讨自拟中药方延玉合剂治疗老年稳定劳力型心绞痛的临床疗效。方法:将80例老年稳定劳力型心绞痛患者随机分为2组,对照组40例给予西医常规治疗,治疗组40例在对照组治疗的基础上加用延玉合剂治疗,比较2组治疗前后的中医证候积分、相关临床指标及远期不良预后事件。结果:中医证候总有效率治疗组为100.0%,优于对照组的85.0%(P<0.05);治疗组治疗后血脂水平、血液流变学指标及内皮功能与本组治疗前及对照组治疗后比较,差异均有统计学意义(P<0.01),且总体远期不良预后事件率明显低于对照组,差异均有统计学意义(P<0.05)。结论:延玉合剂治疗老年稳定劳力型心绞痛的临床疗效显著,具有借鉴意义。

Objective ： To investigate the clinical efficacy of self - made traditional Chinese medicine prescription Yanyu mixture in elderly patients with stable exertional angina pectoris. Methods：Eighty elderly patients with stable exertional angina pectoris were randomly divided into control group （n = 40）and treatment group （n = 40 ）. The con- trol group received conventional Western medicine treatment, while the treatment group was treated with Yanyu mix- ture in addition to the treatment for the control group. The traditional Chinese medicine（TCM） syndrome score, rele- vant clinical indicators, and long -term adverse events were compared between the two groups. Results：The overall response rate for TCM syndromes was significantly higher in the treatment group than in the control group（ 100. 0% vs 85.0% ,P 〈 0. 05 ）. After treatment, the treatment group showed significant improvements in blood lipids, hemo- rheological indices, and endothelial function and had significantly better results in the above indices than the control group （ P 〈 0. 01 ）. In addition, the overall rate of long - term adverse events was significantly lower in the treatment group than in the control group （ P 〈 0. 05 ）. Conclusion ： Yanyu mixture is effective in elderly patients with stable ex- ertional angina pectoris and holds promise for clinical application.