摘要
Two new phragmalin-type limonoids orthoesters, encandollens A and B(1 and 2), were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, ~1 H and ^(13) C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide(LPS)-induced RAW 264.7 cells.
Two new phragmalin-type limonoids orthoesters, encandollens A and B（1 and 2）, were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, ~1 H and ^（13） C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide（LPS）-induced RAW 264.7 cells.
基金
supported by the National Natural Science Foundation of China(Nos.31470416 and 81430092)
the Program for New Century Excellent Talents in University(No.NCET-2013-1035)
the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
the Program for Changjiang Scholars and Innovative Research Team in University(IRT_15R63)
