同型半胱氨酸水平与溃疡性结肠炎相关性的meta分析

The association between homocysteine levels and ulcerative colitis：a Meta-analysis.

目的：对有关同型半胱氨酸（HCY）水平与溃疡性结肠炎（UC）之间相关性研究报道的数据进行Meta分析,为UC早期筛查提供依据.方法：计算机对Pubmed、Elsevier、Web of Science、CNKI、万方数据库进行检索,搜集关于UC患者血HCY水平的病例对照研究,应用分析软件Stata 12.0软件进行Meta分析.结果：共纳入16个研究,2968例研究对象.Meta分析结果显示,UC组与对照组间HCY水平的标准均数差（standard mean difference）为1.28 umol/L[95％CI：（0.93,1.64）].结论：高水平HCY与UC发病关系密切相关.

Objective： This study aims to evaluate the association between ulcerative colitis and homocysteine concentration, and to provide evidence for early diagnosis. Methods： Computer retrieval was performed for plasma homocysteine level among ulcerative colitis and healthy people in Pubmed, Elsevier, Web of Science, CNKL Wanfang Data. Meta analyses were conducted to examine homocysteine level in two groups with Stata 12.0 software. Results： Sixteen studies met inclusion criteria. Homocysteine level standard mean difference （SMD） between the patient group and the control group was 1.28 umol/L [（95%CI： （0.93,1.64）] . Conclusion： High plasma homosysteine level is associated with increasing morbidity of UC.