反转录病毒结合位点-1基因在急性淋巴细胞性白血病中的研究进展

Advances of ecotropic viral integration site 1 gene in acute lymphoblastic leukemia

作为原癌基因,反转录病毒结合位点-1（EVI1）基因在急性髓系白血病（AML）中可因染色体易位或其他遗传学异常而高表达,最终导致预后较差.近年来,EVI1基因在急性淋巴细胞性白血病（ALL）中的研究逐渐增多,尤其在儿童ALL中的研究较多.EVI1基因高表达亦提示预后不良,且与年龄密切相关,但是其与混合谱系白血病（MLL）基因重排及BCR-ABL基因重排的关系有待进一步研究.研究ALL中EVI1基因的表达特点以及探索相应的靶向治疗药物是今后的重要研究方向.

As an proto-oncogene,ecotropic viral integration site 1 （EVI1） gene is over-expressed in acute myeloid leukemia （AML） because of chromosomal translocation or other genetic abnormalities,finally cause poor prognosis.In recent years,an increasing research of the expression of EVI1 in acute lymphoblastic leukemia （ALL）,especially in pediatric ALL.The overexpression of EVI1 gene also suggest a poor prognosis,which is closely relate to the age.But the relationship between the expression of EVI1 gene and mixed lineage leukemia （MLL） and BCR-ABL gene rearrangement needs to be further studied.Researching the expression of EVI1 gene in ALL and exploring targeted therapeutic agents are important research directions in the future.