锯叶棕果实提取物对经尿道前列腺等离子双极电切术后出血量的影响

Effect of saw palmetto extrac on bleeding volume in transurethral plasmakinetics resection of prostate

目的 观察围手术期应用锯叶棕果实提取物对经尿道前列腺等离子双极电切术（transurethral plasmakinetics resection of prostate,TUPKRP）后出血量的影响.方法 将2015年3月至2016年3月本院确诊的150例前列腺增生患者随机分成锯叶棕组、非那雄胺组、对照组.锯叶棕组患者术前口服锯叶棕果实提取物4周,剂量160 mg每日一次,术后继续服用1周;非那雄胺组术前口服非那雄胺4周,剂量5 mg每日一次,术后继续服用1周;对照组术前术后未给予任何药物,3组由同一组医师进行手术.对3组患者的手术时间、术后血红蛋白下降值、术后红细胞压积下降值、术后膀胱冲洗液量进行统计学分析.结果 所有患者均顺利完成手术,围手术期间未发现药物副作用.与对照组相比,锯叶棕组、非那雄胺组的手术时间显著缩短,术后血红蛋白下降值、术后红细胞压积下降值显著降低,术后膀胱冲洗液量显著减少（P＜0.05）.锯叶棕组与非那雄胺组手术时间、术后膀胱冲洗液量、术后血红蛋白下降值、术后红细胞压积下降值比较无显著性差异（P＞0.05）.结论 围手术期应用锯叶棕果实提取物可减少前列腺增生患者术中、术后的出血量、缩短手术时间、减少术后膀胱冲洗液量,有利于患者术后康复,值得有条件的医院推广应用.

Objective To observe the effect of perioperative use of saw palmetto extrac （SPE）on the bleeding volume in transurethral plasmakinetics resection of prostate （TUPKRP）.Methods A total of 150 patients with benign prostate hyperplasia（BPH） were randomly divided into SPE group,finasteride group and control group.Patients in SPE group had taken SPE 160 mg orally once a day for 4 weeks before operation and 1 week after operation.Patients in finasteride group had taken finasteride 0.5 mg orally once a day for 4 weeks before operation and 1 week after operation.None of 50 patients in the control group had taken any drugs.All patients underwent transurethral plasmakinetics resection of prostate by the same surgical team.The operation time,postoperative hemoglobin decrease,postoperative hematocrit decrease and postoperative bladder lavage fluid volume were compared and analyzed among the 3 groups.Results All operations were successful,and none patients treated with SPE and finasteride reported any side effects.The operation time,postoperative hemoglobin decrease,postoperative hematocrit decrease and postoperative bladder lavage fluid volume of SPE group and finasteride group were evidently lower than control group （P ＜ 0.05）.There was no statistical significant difference in operation time,postoperative bladder lavage fluid volume,postoperative hemoglobin decrease and postoperative hematocrit decrease between SPE group and finasteride group （P ＞ 0.05）.Conclusions SPE can reduce postoperative blood loss,the bladder lavage fluid volume,and short the operation time in BPH patients underwent TUPKRP.It is worthy of popularization.