中药莪术几种活性成分对肝脏疾病防治作用的机制

Effects of several active ingredients of Rhizoma curcumae on liver diseases

中药莪术几种主要活性成分如姜黄素、榄香烯、莪术醇、吉马酮对治疗肝脏疾病具有确定的疗效.研究发现姜黄素有抗肿瘤、抗炎、抗纤维化等作用,临床用于治疗慢性肝病、肿瘤等疾病;榄香烯能诱发肿瘤细胞凋亡,抑制肿瘤细胞的生长,提高机体免疫反应,降低放化疗不良反应;莪术醇可以通过抑制细胞因子表达发挥抗肝纤维化作用,并可以通过抑制基因表达诱导瘤细胞的凋亡,发挥抗肿瘤作用;吉马酮则在肝癌细胞的增殖、细胞周期及细胞凋亡等方面均有干预影响,从而呈现抗肝癌作用.

The main active ingredients of Rhizoma curcumae, such as curcumin, elemene, curcumol, and germacrone, have certain curative effect on liver diseases. Studies have found that curcumin has anti-tumor, anti-inflammatory, anti-fibrosis, and other properties and can be used for treatment of chronic liver disease, tumors and other diseases. Elemene can induce tumor apoptosis, inhibit the growth of tumor cells, improve the immune response, and reduce the toxic and side effects of chemotherapy. Zedoary alcohol can exert anti-fibrosis effects by inhibiting the expression of cytokines, and exert anti-tumor effects by inhibiting the apoptosis of tumor cells. Germacrone can intervene hepatocellular cancer cell proliferation, cell cycle, apoptosis, and other aspects, showing anti-hepatocarcinoma effects.