法舒地尔对血管性痴呆患者日常生活能力智力及血液流变学影响

目的探讨Rho激酶抑制剂盐酸法舒地尔对血管性痴呆（VaD）患者日常生活能力、智力及血液流变学的影响。方法选取2013年2月至2015年7月VaD患者169例，按随机数字表法将所有患者分为对照组（83例）和观察组（86例）。对照组患者采用胞二磷胆碱治疗，观察组患者给予盐酸法舒地尔治疗，比较两组患者日常生活能力及智力、血液流变学指标及不良反应。结果两组患者治疗前纤维蛋白原、红细胞压积、血浆粘度和全血粘度等血液流变学指标比较差异无统计学意义（P〉0．05），两组患者治疗后血液流变学指标均明显低于治疗前，且观察组患者治疗后血液流变学指标均明显低于对照组，差异有统计学意义（P〈0．05）。两组患者治疗前WMS、HDS、ADL和MMSE等评分比较差异无统计学意义（P〉0．05），两组患者治疗后各量表评分均明显高于治疗前，且观察组患者治疗后各量表评分均明显高于对照组，差异有统计学意义（P〈0．05）。两组患者均未见明显不良反应。结论盐酸法舒地尔可促进生活能力、记忆能力和认知能力康复，神经功能缺损得到明显改善，且可明显改善VaD患者的脑微循环，且不良反应少，具有较高的安全性，值得临床推广。

Objective To research the influence of activity of daily living, intelligence scale and hemorheology of Rho kinase inhibitors fasudil in the treatment of vascular dementia. Methods 169 vascular dementia patients between February 2013 and July 2015 of our hospital were selected and divided into two groups called control group and research group randomly, the control group was treated by citicoline, while research group was treated by fasudil, compared the activity of daily living, intelligence scale and hemorheology of two groups. Results The fibrinogen, hematocrit, plasma viscosity and whole blood viscosity of two groups pre-treatment had no statistical difference （ P〉0.05 ） , the fibrinogen, hematocrit, plasma viscosity and whole blood viscosity after treatment of research group were much lower than control group （ P〈0.05 ） , and fibrinogen, hematocrit, plasma viscosity and whole blood viscosity after treatment of two groups had statistical difference with pre-treatment respectively （ P〈0.05 ） . The WMS, HDS, ADL and MMSE scale of two groups pre-treatment had no statistical difference （ P〉0.05 ） , the WMS, HDS, ADL and MMSE scale after treatment of research group were much higher than control group （ P〈0.05 ） , and WMS, HDS, ADL and MMSE scale after treatment of two groups had statistical difference with pre-treatment respectively （ P〈0.05 ） .No adverse reactions were observed in the two groups. Conclusion Fasudil can promote the life ability, memory ability and cognitive ability of rehabilitation, neurological deficits are improved significantly, the protections of nerve block, and can significantly improve the cerebral microcirculation of VaD patients, and less adverse reaction, high security, is worthy of promotion.