米索前列醇联合缩宫素对产后出血的治疗效果

Clinical Effect of Misoprostol Combined with Oxytocin in the Prevention and Control of Postpartum Hemorrhage

目的:探讨米索前列醇联合缩宫素对产妇产后出血的治疗效果。方法:将80例产妇分为观察组与对照组,对照组产妇产后给予缩宫素子宫体注射,观察组在对照组治疗的基础上,肛塞给予400μg米索前列醇,观察两组产妇产后出血发生率、产后2、24 h内的出血量、用药后血红蛋白(Hb)和红细胞比容(Hct),并观察两组患者不良反应发生情况。结果:与对照组比较,观察组产妇产后2 h出血量及产后24 h出血发生率显著降低,差异有统计学意义(P<0.05);两组产妇在用药前、后Hct及Hb均降低;对照组产妇的细胞比容及Hb较观察组降低更明显,差异有统计学意义(P<0.05);与对照组比较,观察组产妇的不良反应发生率显著降低,差异有统计学意义(P<0.05)。结论:在缩宫素的基础上联谊米索前列醇能显著降低产妇产后出血情况及产后出血量,安全性高。

Objective： To explore the effect of misoprostol combined with oxytocin in the prevention and control of postpartum hemorrhage. Methods： 80 cases of lying-in women were selected in our hospital from February 2015 to March 2016 for the study and randomly divided into the observation group and the control group. The control group were given oxytocin in the prevention and control of postpartum hemorrhage,while the observation group received misoprostol as well as oxytocin in the prevention and control of postpartum hemorrhage. The two groups were observed in the incidence rate of postpartum hemorrhage,the volume of postpartum bleeding in in 2 h and 24 h and the contrast of hemoglobin（ Hb） and hematocrit（ Hct） after treatment. The incidence of adverse reactions of the patients of both groups was also observed. Results： The incidence rate of postpartum hemorrhage in 2 h and the postpartum hemorrhage volume in 24 h in the observation group were significantly lower compared with those in the control group. The difference was statistically significant（ P〈0. 05）; Hct and Hb of the lyingin women of both groups decreased before and after medications. The maternity Hct and Hb of the control group decreased more significantly than that of the observation group,and the differenc was statistically significant（ P〈0. 05）; The rate of maternal adverse reaction in the observation group was significantly reduced compared with the control group,and the difference is statistically significant（ P〈0. 05）. Conclusion： Misoprostol combined with oxytocin can significantly reduce the incidence of maternal postpartum hemorrhage and postpartum bleeding volume,with high safety and without serious adverse reactions. It is worth of clinical application.