多囊卵巢综合征患者缺血修饰白蛋白的变化及其临床意义

Changes and clinical significance of ischemic modified albumin in patients with polycystic ovary syndrome

目的研究多囊卵巢综合征（polycystic ovarian syndrome, PCOS）患者血清缺血修饰白蛋白（ischemia modified albumin, IMA） 水平变化，并探讨IMA与PCOS代谢异常的相关性。方法选择31例PCOS（PCOS组）和28例年龄、体质量指数（BMI）与PCOS组相匹配的健康女性（对照组）为研究对象。比较2组血清IMA水平和相关生化指标。分析IMA与各指标之间的相关性。结果PCOS组血清IMA水平明显高于对照组（P〈0．05）。相关分析显示，血清IMA水平与睾酮（testosterone）水平呈正相关（r=0．57，P=0．03）。结论PCOS血清IMA水平明显升高且与睾酮密切相关，揭示氧化应激可能参与高雄激素血症的发生和发展。

Objective To investigate the change of ischemia modified albumin （IMA） in polycystic ovary syndrome （PCOS） women, and to examine the relationship between IMA and metabolic disorder. Methods 31 PCOS women （PCOS group） and 28 age- and BMI-matched healthy women （control group） were recruited. Serum IMA levels and related biochemical indexes were compared between the two groups, and the correlation between IMA and each index was analyzed. Results Serum IMA level in PCOS group was significantly higher than that in the control group （P〈0.05）. Correlation analysis showed that serum IMA levels were positively correlated with testosterone levels （r=0.57, P=0.03）. Conclusion Serum IMA levels in PCOS patients are significantly elevated and closely related to testosterone, suggesting that oxidative stress may be involved in the pathogenesis and de- velopment of hyperandrogenemia.