基于“虚、毒、湿”理论培元理肠方治疗老年抗生素相关性腹泻的临床研究

Clinical observation of Peiyuan Lichang formula on senile antibiotic-associated diarrhea

目的:基于"虚、毒、湿"理论,探讨培元理肠方治疗老年抗生素相关性腹泻的临床疗效。方法:选取我院抗生素相关性腹泻老年患者90例,采用随机分组软件(Rand A1.0)分为3组,即试验组、对照Ⅰ组、对照Ⅱ组,每组30例。试验组给予培元理肠方治疗,对照组分别给予培菲康、固肠止泻丸治疗,观察评价治疗前后临床症状积分的变化。结果:试验组总有效率90.00%(95%CI=74.15%~97.90%),对照Ⅰ组总有效率76.67%(95%CI=61.54%~91.80%),对照Ⅱ组总有效率80.00%(95%CI=65.69%~94.31%),3组综合疗效比较(χ~2=3.299 7,P>0.05),差异无显著性意义;试验组总积分下降显著低于对照I组(t=-2.948 7,P<0.01)、对照Ⅱ组(t=3.169 3,P<0.01)。结论:采用培元理肠方治疗AAD的疗效可能优于对照Ⅰ组,其收益为OR=0.37(95%CI=0.08~1.57),NNT=8(95%CI=3.11~25.59)。

Objective ：Based on the theory of ＂deficiency, toxicity and dampness＂, to discuss the clinical effect of Peiyuan Lichang formula on senile antibiotic-associated diarrhea （AAD）. Methods：With randomized grouping software （RandA1.0）, 90 cases of senile patients with antibiotic-associated diarrhea selected from our hospital were divided randomly into three groups, i. e. treatment group, control group Ⅰ and control Ⅱ , 30 cases in each group. The treatment group was treated with Peiyuan Lichang formula, while the control groups were treated respec- tively with Live Combined Bifidobacterium and Guchang Zhixie pills. The change of clinical symptoms scores before and after treatment was observed and evaluated. Results：The total effective rate of treatment group was 90.00% （95% CI =74.15% to 97.90% ）, while the total effective rate of control group I was 76.67% （95% CI =61. 54% to 91.80% ）, the total effective rate of control group Ⅱ was 80.00% （95% CI = 65.69% to 94.31% ）. Compared the comprehensive effect among 3 groups （χ2 = 3. 299 7, P 〉 0.05 ） , the difference was statistically not significant （ P 〈 0.05 ）. The decrease of total score in treatment group was significantly lower than in control groupⅠ （t = - 2. 948 7 ,P 〈 0.01 ） and control Ⅱ （ t = 3. 169 3 ,P 〈 0.01 ）. Conclusion ：The clinical effect of Peiyuan Li- chang formula on AAD may be better than that of control group Ⅰ . Its benefit is OR =0.37 （95% CI =0.08 1.57）, NNT=8 （95% CI =3.11 ~25.59）.