急性冠状动脉综合征患者缺血修饰白蛋白水平与冠状动脉病变程度的相关性研究

Correlation between Ischemia-modified Albumin Levels and Coronary Artery Lesions in Patients with Acute Coronary Syndrome

目的探讨急性冠状动脉综合征(ACS)患者缺血修饰白蛋白(IMA)水平与冠状动脉病变程度的相关性。方法入选ACS患者51例。所有患者入院后均进行冠状动脉造影检查及冠状动脉粥样硬化性心脏病规范治疗,收集冠状动脉造影结果并计算Gensini评分,检测IMA水平。同期选取健康志愿者10例作为对照组。结果冠状动脉病变组IMA水平均高于对照组(P<0.05);但各冠状动脉病变组组间比较IMA水平均无统计学差异。IMA水平与其Gensini评分无相关性;但Gensini评分中度组TIMI血流3级比例低。结论 ACS患者IMA水平升高,但IMA水平与冠状动脉病变程度无相关性,IMA不能准确反映冠状动脉病变程度,IMA水平升高提示心肌缺血处于不稳定状态。

Objective To evaluate the correlation between ischemia-modified albumin （IMA） levels and severity of coronary artery le- sions in patients with acute coronary syndrome （ACS）. Methods This study included 51 in-hospital patients diagnosed as having ACS. All patients had undergone coronary angiography and received the standard treatment for coronary heart disease. Meanwhile ,we included 10 healthy volunteers as the control group. Coronary angiography reports were collected, Gensini scores were calculated,and serum IMA levels were measured. Results The IMA levels of patients with ACS were higher than those of the controls （P 〈 0.05）. However, when di- vided by the degree of coronary artery stenosis, number of vessel lesions, and Gensini scores, the IMA levels showed no significant differ- ence between the groups. The IMA levels were not related with the Gensini scores. The moderate group had a low ratio of TIMI flow grade 3. Conclusion Patients with ACS had higher IMA levels. We found no correlation between IMA level and coronary artery lesions. IMA level may not accurately reflect the severity of coronary artery lesions. Increased IMA level may indicate the unstable status of ischemia.