肠易激综合征基于局部一致性的静息态脑功能成像研究

Regional homogeneity of brain in irritable bowel syndrome patient:a resting state fMRI study

目的应用静息态功能磁共振成像(RS-fMRI)分析肠易激综合征(IBS)患者脑区局部一致性的异常。方法纳入荆州市第一人民医院消化内科自2015年7月至2016年6月收治的23例IBS患者及年龄、性别比例、受教育程度相匹配的23例健康志愿者(对照组)为研究对象,采用3.0T磁共振于静息状态下行fMRI扫描,将获得的静息态数据进行基于局部一致性(ReHo)的分析比较。结果与正常对照组比较,IBS患者组ReHo值升高的脑区有左侧枕叶,ReHo值降低的脑区有右侧岛叶、右侧颞上回、双侧额中回(P<0.001)。结论研究显示静息状态下IBS患者多个脑区的活动存在异常。

Objective To investigate regional homogeneity（ReHo）of brain in patients with irritable bowelsyndrome（IBS）using resting-state functional MRI（rs-f MRI）. Methods 23 patients with IBS and 23 age-,edu-cation-,and sex-matched normal healthy subjects（control group）were collected in our hospital from July 2015 toJune 2016. All of them underwent rs-fMRI. The rs-fMRI data were analyzed with the regional homogeneity method.Results As compared with the control group,the IBS group showed significantly increased ReHo values in theleft occipital lobe,and decreased ReHo values in the right insular,the right superior temporal gyrus and bilateralmiddle frontal gyrus（P 0.001）. Conclusion One or more brains of the IBS patients showed significant differ-ences in the spontaneous neuronal activity compared with healthy controls.