清补地龟汤治疗气虚湿热型慢性肾脏病3期的队列研究

A cohort study on treatment of chronic kidney disease 3 with qi deficiency and dampness-heat typebyqingbudigui decoction

目的评价清补地龟汤延缓气虚湿热型慢性肾脏病(CKD)3期进展的临床疗效。方法采用回顾性队列研究的方法,纳入103例气虚湿热型CKD3期患者,其中对照组51例予西医基础治疗,治疗组52例加服清补地龟汤;比较12、24个月后血肌酐(SCr)、肾小球滤过率估算值(eGFR)、24 h尿蛋白定量(U-Pro)的变化。结果治疗组12、24个月后SCr、U-Pro水平下降,差异有统计学意义(P<0.01),eGFR水平上升,差异有统计学意义(P<0.01,P<0.05);对照组治疗后SCr、U-Pro、eGFR比较差异均无统计学意义(P>0.05)。结论清补地龟汤能够减少气虚湿热型CKD3期患者蛋白尿,延缓肾脏病进展。

Objective To evaluate the clinical effects of the treatment on chronic kidney disease 3 withdampness-heat type. Methods A retrospective cohort study recruited 103 patients with qi deficiency and dampness-heat type of CKD3. Among them,51 cases in the control group were treated with western medicine therapy. The52 cases in the treatment group received Qingbudigui Decoction. SCr,eGFR and 24 h U-Prowere were observed after12 months and 24 months for evaluating the clinical effects of Qingbudigui Decoction. Results After 12 and 24 months treatment,the treatment group had a significantly lower SCr and U-Pro（P 0.01）,but a higher eGFR（P 0.01,P 0.05）. After 12 months and 24 months,there was no significant change in SCr,U-Pro or eGFR inthe control group（P 0.05）. Conclusions Combination therapy of the Qingbudigui Decoction of the patientswith qi deficiency and dampness-heat type of CKD3 could delay the kidney disease,which is superior to simplewestern medicine group. The mechanism may be related to the reduction of urinary protein excretion.