HOXA7在口腔鳞状细胞癌组织中的表达及临床意义

Expression and clinical significance of HOXA7 in the Oral Squamous Cell Carcinoma

目的研究同源盒基因A7(homeobox protein hox-A7,HOXA7)mRNA在口腔鳞状细胞癌组织(oral squamous cell carcinoma,OSCC)中的表达。方法收集20例口腔正常粘膜组织及42例OSCC组织,利用实时荧光定量聚合酶链反应(real-time quantitative program control register,Real-Time q PCR)检测HOXA7mRNA的相对表达情况。结果对比口腔黏膜组织,HOXA7mRNA在OSCC中高表达(z=-5.739,P<0.050),不同分化程度(z=-0.863,P<0.05),不同临床分期(z=-0.756,P<0.05),组间差异有统计学意义。不同年龄(z=-0.619,P>0.05)、不同性别(z=-1.801,P>0.05),组间差异无统计学意义。结论 HOXA7mRNA在口腔鳞状细胞癌组织中高表达,并且与肿瘤分化和临床分期有关,HOXA7可能作为口腔癌治疗和口腔鳞癌早期诊断的潜在生物标记物。

Objective To detect the expression of homeobox A7（HOXA7）gene mRNA in oral squamous cell carcinoma（OSCC）.Method Real-time absolute quantitative PCR（qPCR）detected the expression of HOXA7 mRNA in 42 OSCC and 20 normaloral mucosa tissues.Results HOXA7 mRNA was found to be highly expressed in OSCC（z=-5.739,P〈0.05）and its mRNA correlated significantly with the different degree of differentiation（z=-0.863,P〈0.05）and clinical stage（z=-0.756,P〈0.05）.But did not find any significant differences in age（z=-0.619,P〉0.05）and gender（z=-1.801,P〉0.05）.Conclusion The study found that HOXA7 gene mRNA are highly expressed in OSCC and that the expression level is correlated with the degree of tumor differentiation and clinical stages.The findings implicate HOXA7 as potential targets for cancer therapeutics and as early OSCC diagnostic biomarkers.