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IL-33及ST2与纤维化疾病的研究进展 被引量:2

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摘要 白细胞介素33(interleukin-33,IL-33)是研究报道[1]2005年新发现的一个细胞因子。人类的IL-33基因位于9p24.1区域,其编码的多肽分子以3.0×104的前体蛋白形式存在于细胞核内,经半胱氨酸蛋白酶-1(caspases-1)剪切加工成1.8×104的成熟蛋白后分泌到胞质中。人类IL-33mRNA高表达于全身多个组织器官,
作者 赵文静 陆爽
出处 《贵州医药》 CAS 2017年第9期999-1001,共3页 Guizhou Medical Journal
关键词 纤维化 IL-33 ST2
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  • 1孔琪,秦川.肺纤维化的发病机制及关键靶点[J].国外医学(呼吸系统分册),2005,25(5):331-333. 被引量:34
  • 2SCHMITZ J, OWYANG A, OLDHAM E, et al. IL-33, an inter- leukin-l-like cytokine that signals via the IL-1 receptorrelated protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23: 479-490.
  • 3CHACKERIAN AA. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J]. J Immunol, 2007, 179: 2551-2555.
  • 4PASTORELLI L, GARG RR, HOANG SB, et al. Epithelial-de- rived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Thl/Th2 driven enteritis[J]. Proc Natl Acad Sci USA, 2010, 107: 8017-8022.
  • 5SEIDELIN JB, BJERRUM JT, COSKUN M, et al. IL-33 is up- regulated in colonocytes of ulcerative colitis [J]. Immunol Lett, 2010, 128: 80-85.
  • 6KOBORI A, YAGI Y, IMAEDA H, et al. Interleukin-33 expres- sion is specifically enhanced in inflamed mueosa of ulcerative colitis[J]. J Gastroenterol, 2010, 45(10): 999-1007.
  • 7SZAPIEL SV, ELSON NA, FULMER JD, et al. Bleomycin-in- duced interstitial pulmonary disease in the nude athymic mouse [J]. Am Rev Respir Dis, 1979, 120: 893-899.
  • 8KUROKAWA M, MATSUKURA S, KAWAGUCHI M, et al. Ex- pression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts[J]. Int Arch Allergy Immunol, 2011, 155(suppl 1): 12-20.
  • 9Schmitz J,Owyang A,Oldham E,et al.IL-33,an interleukin-1like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].Immunity,2005,23(5):479-490.
  • 10Beltrán C J,Núnez LE,Díaz-Jiménez D,et al.Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease[J].Inflamm Bowel Dis,2010,16 (7):1097-1107.

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