不同年龄病人冻融单囊胚移植的妊娠结局和出生结局比较

Comparison of the pregnancy and birth outcome of single frozen-thawed blastocyst transfer in patients of different ages

目的:比较不同年龄病人冻融单囊胚移植后的妊娠结局和出生结局。方法:回顾性分析2012年8月至2014年8月冻融单囊胚移植的2 414个周期,按照<35岁和≥35岁2个年龄段分别比较第5天(D5组)与第6天(D6组)冻融单囊胚病人复苏移植后的临床妊娠率、囊胚种植率、流产率、异位妊娠率、多胎妊娠率、早产率、低出生体质量率、出生缺陷率、新生儿死亡率等指标。结果:病人无论年龄大小,D5组的临床妊娠率和囊胚种植率均明显高于D6组(P<0.01);而2组流产率、多胎妊娠率、早产率、低出生体质量率、出生缺陷率和新生儿死亡率,差异均无统计学意义(P>0.05)。在<35岁病人中,D5组的异位妊娠率高于D6组(P<0.01)。结论:病人无论年龄大小,第5天单囊胚和第6天单囊胚在复苏移植后都有较好的妊娠结局和出生结局,但总体上看第5天要优于第6天,建议优先选择第5天单囊胚复苏移植。

Objective：To compare the pregnancy and birth outcome of single frozen-thawed blastocyst transfer in patients of different ages. Methods：The data of 2414 cycles of single frozen-thawed blastocyst transfer were retrospectively analyzed. The clinical pregnancy rate,implantation rate,abortion rate,ectopic pregnancy rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between the fifth day and sixth day of single frozen-thawed blastocyst transfer（ group D5 and group D6） were compared in patients less than 35 years old and patients more than or equal to 35 years old. Results：Regardless of age,the clinical pregnancy rate and implantation rate in group D5 were higher than those in group D6（P〈0. 01）. The differences of the abortion rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between group D5 and D6 group were not statistically significant（P〉0. 05）. Among the patients less than 35 years old,the ectopic pregnancy rate in group D5 was higher than that in group D6（P 〈0. 01）. Conclusions：Regardless of patients＇ age,the pregnancy outcome and birth outcome of the day 5 and day 6 single blastocyst transfer are good,and that of the day 5 is better than that of the day 6,and the days singk frozen-thawed blastocyst transfer should be the first choice.