神经生长因子对脑出血病人神经功能缺损及骨桥蛋白表达的影响

Effect of the nerve growth factor on nerve dysfunction and osteopontin expression in patients with intracerebral hemorrhage

目的:观察神经生长因子(NGF)治疗脑出血的临床疗效,并探讨NGF对病人神经功能缺损、Barthel指数(BI)评分及骨桥蛋白(OPN)表达的影响。方法:将84例脑出血病人采用随机数字法分为观察组与对照组,各42例。对照组病人接受神经内科常规治疗并给予胞磷胆碱,观察组病人在常规治疗基础上予以NGF联合治疗,连续治疗2周。比较2组病人美国国立卫生研究院卒中量表(NIHSS)评分、BI评分、OPN水平以及临床治疗效果等指标。结果:治疗前,2组病人NIHSS评分、血清OPN水平、BI评分差异均无统计学意义(P>0.05),治疗后2组OPN水平及NIHSS评分均明显下降,且观察组OPN水平及NIHSS评分下降程度均明显高于对照组(P<0.01),而2组治疗后BI评分均明显增加,且观察组BI评分增高程度明显高于对照组(P<0.01);观察组的治疗总有效率(90.5%)高于对照组(71.4%)(P<0.05);观察组疗效优于对照组(P<0.05)。结论:采用NGF对脑出血病人进行治疗效果显著,能够有效改善病人的临床症状和神经功能缺损程度,降低血清OPN水平,促进病人恢复,安全性高,临床上值得继续推广。

Objective：To explore the clinical effects of the nerve growth factor（NGF） in the treatment of intracerebral hemorrhage, and effects of NGF on the nerve dysfunction,Barthel index（ BI） score and osteopontin（ OPN） expression. Methods：Eighty-four patients with intracerebral hemorrhage were randomly divided into the control group and observation group using random number method （ 42 cases each group）. The control group was treated with conventional method combined with citicoline,and the observation group was additionally treated with NGF based on conventional method for 2 weeks. The National Institutes of Health Stroke Scale（ NIHSS） and BI scores,OPN expression level and clinical efficiency between two groups were analyzed and compared after treatment. Results：The differences of the NIHSS and BI scores,and OPN expression level before treatment between two groups were not statistically significant （P＆gt;0. 05）. After treatment,the NIHSS score and OPN expression level in two groups significantly decreased,and the decreasing degree of those in observation group was significantly higher than that in control group（P〈0. 01）. After treatment,the BI scores in two groups significantly increased,and the increasing degree of which in observation group was significantly higher than that in control group （P〈0. 01）. The total effective rate of treatment in observation group（90. 5%） was higher than that in control group（71. 4%）（P〈0. 05）. The curative effect in observation group was better than that in control group（P〈0. 05）. Conclusions：The effect of NGF in the treatment of intracerebral hemorrhage is significant and safe,which can effectively improve the clinical symptoms and nerve dysfunction, reduce the OPN level,promote the recovery of patients,and is worthy of promotion.