SAA和CRP联合检测在小儿感染性疾病鉴别诊断中的应用价值评价

Evaluation of combined use of SAA and CRP in the differential diagnosis of infectious diseases in children

目的分析研究血清淀粉样蛋白A(SAA)和C-反应蛋白(CPR)在小儿感染性疾病鉴别诊断中的应用价值。方法选取我院2015年3月~2017年2月间收治的小儿感染性疾病患儿500例作为研究对象,按照其细菌培养或者病毒鉴别的结果将其分为细菌性感染组(293例)和病毒性感染组(207例),分别对其SAA、CRP等指标进行检测,并取同期接受体检的健康儿童各200例作为对照,行相同检测,比较各组受检儿童两项指标检测结果之间的差异。同时计算SAA、CRP单独或联合诊断小儿细菌性感染性疾病的灵敏度、特异性以及准确度。结果对各组儿童的SAA和CRP检测结果进行比较,均有细菌性感染组患儿显著高于病毒性感染组患儿和健康儿童的情况,其中病毒性感染组患儿的SAA显著高于健康儿童,差异有统计学意义(P<0.05)。对SAA、CRP单独或联合诊断小儿细菌性感染性疾病的灵敏度、特异性以及准确度进行比较,则有联合诊断显著优于SAA或CRP单独诊断的效果比较有统计学差异(P<0.05)。结论联合应用SAA与CRP对感染性疾病患儿进行诊断,不仅能对患儿的患病情况进行诊断,还能对细菌性感染与病毒性感染进有效鉴别,操作简便易行,特异性俱佳,是一项理想的诊断指标。

Objective To investigate the value of serum amyloid A（SAA） and C- reactive protein（CPR） in the differential diagnosis of infectious diseases in children. Methods 500 cases children admitted to the pediatric infectious disease was selected as the research object in our hospital between March 2015 and February 2017, they were divided into bacteria｜ infection group（293 cases） and viral infection group（207 cases） according to the identification of the virus or bacteria , were used to detect the SAA, CRP and other indicators. 200 cases healthy children underwent as control, for the same detection, compared the differences between all groups by the two indicators of child detection results, calculated the sensitivity, specificity and accuracy of SAA and CRP alone or in combination for the diagnosis of bacterial disease in children. Resluts Bacterial infection group with SAA and CRP test results were significantly higher than the group of viral infection children and healthy children, the virus infection＇ s SAA test resu｜ts were significantly higher than in healthy children, the difference was statistically significant（P 〈 0.05）. The sensitivity, specificity and accuracy of combined diagnosis of SAA and CRP in children with bacterial susceptibility diseases were significantly better than those of SAA or CRP, and there was a statistically significant difference between them（P 〈 0.05）. Conclusion The combined application of SAA and CRP for diagnosis of infectious diseases in children, can not only diagnose the prevalence of children, but also to bacterial infection and virus infection in effective identification, simple operation, high specificity, is an ideal diagnostic index.