罗红霉素聚乳酸多孔微球的体外释药性能研究

Study on the Drug Release Property of Roxithromycin Polylactic Acid Porous Microspheres in Vitro

目的对聚乳酸多孔微球的制备方法、形貌及体外释药性能进行研究。方法采用乳化溶剂挥发法制备罗红霉素聚乳酸微球,用电子扫描显微镜(SEM)测试微球的形貌,用紫外分光光度法(UV)测定微球的体外释药量。结果微球的形态圆整、多孔,两种微球的算术平均粒径分别为49 um和76 um。随投药比增大,微球粒径变小,释药速率变快;12 h体外累积释药量分别为37%和42%。结论聚乳酸多孔微球具有很好的缓控释性能。

Objective To study the preparation process,pattern and drug release property in vitro ofPolylactic acid porous microspheres. Methods Roxithromycin polylactic acid microspheres wereprepared by emulsifying solvent evaporation process.The pattern of the particles were observed throughscanning electron micrograph（SEM）,and amounts of cumulative release in vitro was determined by theultraviolet spectrophotometry（UV）.Results The microspheres were round and its surface was smoothand porous. The arithmetic mean diameter of the two kinds of microspheres were 49 um and 76 um.Microsphere diameter became smaller,and drug release rate increased with the increase of dosage ratio.The cumulative release percentage were 37% and 42% respectively in 12 hour.Conclusion The slowcontrolled release property of Polylactic acid porous microspheres was good.