低剂量尿激酶与重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死的效果比较

Comparison of Therapeutic Effects of Low-dose Urokinase and Recombinant Tissue Plasminogen Activator Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction

目的:比较低剂量尿激酶与重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死的效果。方法:对本院2015年1月-2017年1月收治的80例急性脑梗死患者的临床资料进行回顾性分析,依据静脉溶栓方法,将患者分为低剂量尿激酶组(低剂量UK组,n=40)和重组组织型纤溶酶原激活剂组(rt-PA组,n=40)。对两组患者的NIHSS评分、BI评分、改良Rankin评分、临床疗效及不良反应发生情况进行统计分析。结果:治疗后,rt-PA组患者的NIHSS评分、改良Rankin评分均显著低于低剂量UK组(P<0.05),BI评分显著高于低剂量UK组(P<0.05),治疗总有效率为95.0%(38/40),显著高于低剂量UK组的77.5%(31/40)(P<0.05)。rt-PA组患者的不良反应发生率为15.0%(6/40),低剂量UK组为20.0%(8/40),两组比较差异无统计学意义(P>0.05)。结论:重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死的效果较低剂量尿激酶显著,值得推广。

Objective：To compare the therapeutic effects of low-dose urokinase and recombinant tissue plasminogen activator intravenous thrombolysis in the treatment of acute cerebral infarction.Method：The clinical data of 80 patients with acute cerebral infarction treated in our hospital from January 2015 to January 2017 were retrospectively analyzed,according to the method of intravenous thrombolysis,patients were divided into low dose urokinase group （low-dose UK group,n=40） and recombinant tissue plasminogen activator group （rt-PA group,n=40）.The NIHSS score,Barthel Index,modified Rankin score,clinical efficacy and of adverse reactions of the two groups were statistically analyzed.Result： After treatment,the NIHSS score and modified Rankin score of the rt-PA group were significantly lower than those of low-dose UK group（P〈0.05）,the Barthel Index score was significantly higher than that of low-dose UK group（P〈0.05）,the total effective rate was 95.0%（38/40）was significantly higher than 77.5%（31/40） of the low-dose UK group（P〈0.05）,the differences were statistically significant.The incidence of adverse reactions in group rt-PA was 15.0% （6/40）,and 20.0% in the low-dose UK group（8/40）,there was no significant difference between the two groups（P〉0.05）.Conclusion：The therapeutic effects of recombinant tissue plasminogen activator intravenous thrombolysis in the treatment of acute cerebral infarction is more significant than low-dose urokinase,deserve to spread.