肠泰合剂联合甲氰咪胍治疗婴幼儿胃食管返流病的临床研究

Clinical effects of Changtai mixture plus cimetidine for infantile gastroesophageal reflux disease

目的:探讨肠泰合剂联合甲氰咪胍治疗婴幼儿胃食管返流病的临床疗效。方法:选择2012年1月~2016年11月我院诊治的胃食管返流病患儿74例为观察组,选择同期我院收治的胃食管返流病患儿66例为对照组,两组均予体位干预和饮食治疗。对照组在此基础上予多潘立酮口服,观察组在此基础上予肠泰合剂口服联合甲氰咪胍静脉注射或口服。比较治疗前、治疗后4周两组患儿恶心、呕吐、呛咳、夜间阵发性咳嗽、睡眠不安症状评分。结果:治疗前两组恶心、呕吐、呛咳、夜间阵发性咳嗽、睡眠不安等症状评分差异无统计学差异(P>0.05);治疗后4周,各症状评分均降低,观察组各症状评分均低于对照组,差异有统计学意义(P<0.05)。结论:肠泰合剂联合甲氰咪胍治疗婴幼儿胃食管返流病疗效优于多潘立酮。

Objective To explore the effects of Changtai mixture plus cimetidine for infantile gastroesophageal refux disease. Methods： 74 cases of infantile gastroesophageal refux disease in our hospital from Jan.2012 to Nov.2016 were selected as observation group and another 66 cases of infantile gastroesophageal refux disease in the same period were selected as control group. All the cases were taken position intervention and dietary therapy. In addition, the cases in control group were taken domperidone orally and the observation group was taken Changtai mixture plus cimetidine orally or intravenously. The symptom scores of nausea, emesis, cough, paroxysmal cough and restless sleep before and 4 weeks after treatment were compared. Results： There was no signifcant difference of nausea, emesis, epigastric pain, cough, paroxysmal cough and restless sleep before treatment （P〉0.05）. 4 weeks after treatment, the symptom scores were decreased in the two groups and all the symptom scores in observation group were lower than control group with signifcant difference （P〈0.05）. Conclusion： The effects of Changtai mixture plus cimetidine were signifcantly superior to domperidone for infantile gastroesophageal refux disease.