血清尿酸与进行性核上性麻痹的相关性研究

Serum uric acid associated with progressive supranuclear palsy:a correlation study

目的探讨血清尿酸与进行性核上性麻痹(PSP)的相关性。方法收集71例PSP患者,选取70例健康人群为对照组。采用两独立样本t检验比较PSP组与健康对照组血清尿酸的差异,比较不同性别、PSP各亚型之间以及各亚型与对照组之间血清尿酸差异,采用Spearman分析PSP血清尿酸与Hoehn-Yahr分期、统一帕金森病(PD)评定量表第Ⅲ部分(UPDRSⅢ)评分及病程的相关性。结果 PSP组UPDRSⅢ评分、PSPRS评分明显高于健康对照组(P<0.05)。而PSP组尿酸则明显低于健康对照组(P<0.05)。按不同性别比较时,男性PSP组尿酸明显低于女性(P<0.01),亦低于男性健康对照组(P<0.01)。PSP各亚型尿酸均明显低于健康对照组(P<0.05),差异均有统计学意义。Spearman相关分析,HY分期、UPDRSⅢ评分与尿酸呈明显负相关,而病程与尿酸呈显著负相关(P<0.01)。结论血清尿酸减低可能与PSP患病相关,尤其是男性患者,血清尿酸越低,PSP患病越严重;尿酸作为抗氧化剂,对PSP患者可能具有一定的保护作用。

Objective To explore the correlation between scrum uric acid and progressive supranuclear palsy（PSP）.Methods 71 patients were selected as the PSP groups 70 healthy people as control group/The test was used to compare scrum uric acid between PSP patients and controls.By comparing scrum uric acid for different genders a- mong subtypes of the PSP group with their counterparts in the control group/The relevancand H-Y,UPDRS H and disease duration was calculated by Spearman correlation coefficients.Results TheUPDRS H 〉PSPRS of PSP group were significantly higher than the controls （P 〈0.05）. However？the scgroup were significantly lower than the controlsCP〈0.05）.＂When the male and female groups were investigated sep-arately,he decrease of scrum uric acid was more significant in the male groups compared to the female （P〈0.0 1） , also lower than the male controls （P 〈0.01 ） .Scrum uric acid in subtypes of the PSP than the controlsP 〈0.05） .Scrum uric acidwas a inverse association between H-YandUPDRS H , however,scrum uric acid was in a significantly negative correlation with disease durationCP 〈0.01）.（Concluuric acid may be associated with PSP？especially in the male,the lower scrum uric acid ,he more um uric acid as a natural antioxidant？it could be a natural protective factor in PSP.