肠道菌群在非酒精性脂肪性肝病中作用机制的研究进展

The role of gut microbiota in non-alcoholic fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)已经成为最常见的慢性肝脏疾病之一。近年来研究发现,肠-肝轴在NAFLD的发生、发展中起着重要作用。作为肠-肝轴重要组成部分,肠道菌群通过增加宿主能量摄入、调节胆碱及胆汁酸代谢、激活模式识别受体(pattern recognition receptors,PRRs)而促发炎症反应等机制,促使NAFLD的发生、发展;益生菌对NAFLD有一定疗效进一步证实肠道菌群在NAFLD中发挥着重要作用。本文对肠道菌群在NAFLD发病中可能的作用机制作一概述。

Non-alcoholic fatty liver disease（ NAFLD） has become one of the most common chronic liver diseases.Recent years,many studies have found that gut-liver axis plays an important role in the pathogenesis of NAFLD. As an important part of the gut-liver axis,gut microbiota contributes to the development of NAFLD by enhancing energy intake,regulating the choline and bile acid metabolism,and activating the pattern recognition receptors（ PRRs） which promote inflammation. Probiotics are beneficial for NAFLD,which support that gut microbiota plays an important role in NAFLD. This article reviewed the possible role of gut microbiota in the pathogenesis of NAFLD.