姜黄素对非酒精性脂肪性肝病的作用研究

The relationship between curcumin and non-alcoholic fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是最常见的慢性肝病之一,包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)、肝纤维化、肝硬化及肝细胞癌。NAFLD的发病机制复杂,胰岛素抵抗(IR)与氧化应激共同参与了NAFLD的发生与发展,NF-κB信号通路的激活可能是NAFLD重要的发病机制之一。近年来,由于姜黄素具有调脂、抗氧化、抗炎、护肝等功能,越来越受到学界的重视,极有可能成为NAFLD潜在的治疗药物。本文就姜黄素对NAFLD的研究进展作一概述。

Non-alcoholic fatty liver disease（ NAFLD） is one of the most common chronic liver diseases,its disease spectrum contains simple steatosis,non-alcoholic steatohepatitis（ NASH）,fibrosis,cirrhosis and hepatocellular carcinoma（ HCC）. The pathogenesis of NAFLD is rather complicated,both insulin resistance（ IR） and oxidative stress involved in its occurrence and progress. NF-κB singnal pathway activation could be a crucial mechanism. Recently,curcumin has been an increasingly hot spot in medical field,due to its multiple pharmacological effects,such as regulate hyperlipidemia,antioxidant,anti-inflammation,hepatic protection. Based on numerous evidences of studies,curcumin has enormous potential to be one of the therapeutic drugs for NAFLD. This review focused on research status about the potential relationship between curcumin and NAFLD.