高尔基体糖蛋白-73对肝细胞癌诊断价值的研究进展

Research progress of the diagnostic value of Golgi glycoprotein 73 in hepatocellular carcinoma

临床上,血清甲胎蛋白(alpha-fetoprotein,AFP)是应用最广泛的肝细胞癌肿瘤标志物。但是,仍存在30%~40%的血清AFP阴性的肝细胞癌患者,对于此类患者需要一种新的敏感性更高的肿瘤标志物以提高对肝细胞癌的检出率。近年来,高尔基体糖蛋白-73(GP73)作为一种新的血清肝细胞癌标志物引起了众多学者的广泛关注,其对肝细胞癌诊断价值的大量研究和分析结果表明,GP73在肝细胞癌血清学诊断中的敏感性优于AFP,因此,GP73可作为诊断肝细胞癌的敏感性指标之一。

Clinically,serum alpha-fetoprotein（ AFP） is the most widely used biomarker of hepatocellular carcinoma（ HCC） clinically. But,there are still 30%-40% patients negative,so,a new serum tumor marker of HCC that much more sensitive is needed to improve the diagnostic rate. In recent years,Golgi glyprotein 73（ GP73） has been caused extensive concern and a lot of studies have been done to investigate the value of GP73 in the diagnostis of HCC. The results have shown that the sensitivity and specificity of GP73 in the diagnosis of HCC are superior to AFP,so,it can be used as the index of diagnosis of HCC.