芪苈强心胶囊对老年慢性心力衰竭患者心功能、血浆脑钠肽、D-二聚体及肌钙蛋白Ⅰ的影响

The effect of Qiliqiangxin capsule on serum BNP,D-Dimer and cTnI in patients with chronic heart

目的观察芪苈强心胶囊对老年慢性心力衰竭(CHF)患者心功能、血浆脑钠肽(BNP)及D-二聚体(D-D)、肌钙蛋白Ⅰ(cTnI)的影响。方法收集2014年12月-2016年12月四川省绵阳市中医医院内6科收治老年CHF患者84例为研究对象,随机分为对照组和观察组,每组42例对照组采用常规治疗,观察组在常规治疗基础上加服芪苈强心胶囊。比较2组患者临床疗效,治疗前后的6 min步行试验距离及心脏相关超声指标、血浆BNP、D-D、cTnI的变化。结果观察组患者总有效率为92.86%明显高于对照组的66.67%(X^2=11.648,P<0.05)。与治疗前比较,2组治疗后6 min步行试验距离均有所增加,SV、LVED、LVEF均改善,且治疗后观察组优于对照组(t=4.461、2.387、3.706、4.482,P均<0.01);2组血浆BNP及D-D、CTnI水平均有所下降,治疗后观察组下降幅度大于对照组(t=6.108、5.891、7.102,P均<0.05)。结论芪苈强心胶囊可改善患者心功能及6 min步行试验距离,对老年性慢性心力衰竭患者有明显的治疗作用,值得在临床上推广及应用。

Objective To investigate the effect of Qiliqiangxin capsule on serum BNP and D-Dimer,cTnl of patients with chronic heart failure. Methods Eighty-four patients with chronic heart failure according to the random number table method were divided into control group and observation group. Observation group had 42 patients,in the conventional manner plus Qiliqiangxin capsule treatment; control group of 42 patients were treated in a conventional manner. Analyzing of two groups of patients before and after treatment, the levels of plasma BNP, D-Dimer, cTnl, 6 minute walk distance and cardiac ultrasound indicators and related clinical total efficiency. Results The efficiency of observation group(92.86%) was significantly higher than control group(66.67%), the different was statistically significant( X^2 =11. 648, P < 0. 05). Compared with that before treatment,the 6 min walk distance SV,LVEDD and LVEF were improved in both groups,and the observation group was superior to control group( t =4.461,2.387,3.706,4.482, P <0.01). Two groups of patients' plasma BNP and D-Dimer, cTnl levels were decreased compared to before treatment, but the observation group was better than the control group with statistically significant different( t =6. 108,5. 891,7. 102, P <0. 05);Conclusion It proved that the Qiliqiangxin capsule could effectively improve patients' heart function, enable the plasma BNP and D-Dimer, cTnl levels significantly reduced, which helped to treat chronic heart failure, worthy of promotion and application in clinical practice.