摘要
DNA甲基化转移酶催化基因CpG岛并选择性添加甲基,引起DNA甲基化,使某些区域DNA构象变化,阻止转录因子与启动子结合,并进而抑制基因转录。DNA甲基化与炎症反应密切相关。本文总结DNA甲基化对炎性因子和炎性信号通路的调控机理,以及炎性因子对DNA甲基化转移酶的活化机制。概述炎症反应中DNA甲基化尚待解决的问题,展望DNA甲基化在揭示人类疾病机制,新型药物开发等方面的发展前景。
DNA methylation is that DNA methyltransferases catalyze the Cp G island of genes and selectively add methyl,leading to DNA conformational changes in certain areas,further preventing binding transcription factors to promoter,which ultimately inhibits gene transcription. DNA methylation is closely related to inflammation. This paper summarized regulated mechanism of DNA methylation on inflammatory factors and inflammatory signaling pathways,and activated mechanism of DNA methyltransferases induced by inflammatory factors. Additionally,it outlined some unresolved problems about DNA methylation in inflammatory response,and outlooked the prospect of DNA methylation in revealing the mechanism of human diseases,and in developing new drugs.
出处
《生理科学进展》
CAS
CSCD
北大核心
2017年第5期335-340,共6页
Progress in Physiological Sciences
基金
国家自然科学基金(31572575和31272614)
中央高校基本科研业务费专项基金(2662016PY115)资助课题
关键词
DNA甲基化
炎症
MIRNA
炎性因子
信号通路
DNA methylation
catalyze
genes
selectively
conformational changes
transcription
outlined
