硫酸/辛烷磺酸钠催化酮肟Beckmann重排反应研究

Study on Beckmann Rearrangement of Ketoximes Catalyzed by Sulfur Acid/Sodium Octane Sulfonate

建立了一种高效的硫酸/辛烷磺酸钠催化酮肟发生Beckmann重排反应合成酰胺的方法,该方法以硫酸/辛烷磺酸钠为催化剂,以乙腈为溶剂,在80℃下反应2.5 h,即可获得较高产率的目标化合物。该方法具有反应迅速、反应条件温和、合成效率高等优点,不仅减少了强酸的用量,而且后处理简便。进一步研究表明,该方法具有较好的适用性,为酰胺类化合物的合成提供了一种有效方法。

gAn efficient sulfur acid/sodium octane sulfonate catalyzed by rearrangement reaction of ketoximes to synthesize amide was developed.The desired amides were obtained in good yields under the optimal reaction conditions of H_2SO_4（10 mol%）/C_8H_（14）SO_3 Na（10 mol%） in 80 ℃ for 2.5 h in acetonitrile.The method had advantages of fast reaction rate,mild reaction condition and high yield,which reduced the amount of sulfuric acid and simplified the procedure.Furthermore,the reaction was compatible with a wide range of ketoxime substrates and provided a facile access to the amide.