119例药品不良反应报告回顾性分析

Retrospective Analysis of 119 Cases of Adverse Drug Reactions

目的分析药品不良反应的发生特点及规律,为临床合理用药提供参考。方法整理医院2015年12月1日至2016年11月30日上报的119例不良反应报告,按患者一般情况、用药情况、不良反应发生情况及转归等进行分类统计和分析。结果 119例药品不良反应报告中,主要涉及的药品是抗菌药物;主要表现在皮肤及其附件损害、胃肠系统损害、全身性损害等;严重不良反应主要是抗肿瘤药导致的骨髓抑制及抗菌药物导致的肝功能异常。结论应及时向医生反馈不良反应分析结果,提醒临床重视药品的安全性,在合理使用的基础上,加强用药监护,以预防不良反应的发生。

Objective To analyze the characteristics and regularity of adverse drug reactions,and to provide reference for clinical rational drug use. Methods Totally 119 cases of adverse drug reactions reported by our hospital from December 1,2015 to November 30,2016 were sorted out and analyzed according to the general situation of patients,the situation of drug use,the occurrence of adverse drug reactions and the outcome. Results In 119 cases of adverse drug reactions,the main drugs involved were antibiotics,mainly manifested in the skin and its accessories damage,gastrointestinal system damage,systemic damage,the serious adverse drug reactions were mainly bone marrow suppression caused by antineoplastic drugs and abnormal liver function induced by antibiotics. Conclusion The analysis results of adverse drug reactions should be timely feedback to the doctors, and the clinical importance of drug safety should be reminded. On the basis of rational drug use, the patient medication monitoring should be strengthened in order to prevent the occurrence of adverse drug reactions.