病理组织取材与制片对诊断早期宫颈癌及癌前病变的研究

Research on Pathological Tissue Materials Drawing and Production in Diagnosis of Early Cervical Carcinoma and Precancerosis

目的研究病理组织取材与制片对诊断早期宫颈癌及癌前病变的临床意义。方法该研究中方便选取该院自2011年1月—2016年1月期间宫颈癌普查中液基细胞学检查结果为高级别鳞状上皮内病变的100例患者作为研究对象。该组患者分别应用两种方法进行处理,将按照传统取材结合传统包埋所制片病理组织作为对照组,将定位活检结合宫颈组织黏膜层向下定向包埋所制片病理组织作为观察组。以术后病理诊断结果为金标准,对患者不同方法下的宫颈活检结果进行对比分析。结果以术后病理诊断结果为金标准,100例患者中共检出宫颈上皮内瘤变II患者38例,检出宫颈上皮内瘤变III患者51例,检出微小浸润癌患者7例,总检出率为96.00%(96/100)。观察组病理组织诊断结果与术后病理诊断结果的符合率为93.75%(90/96),显著高于对照组,差异有统计学意义(P<0.05)。结论定位活检取材结合宫颈组织黏膜层向下定向包埋所制片病理组织对早期宫颈癌及癌前病变的诊断效果确切,检出阳性率高,与术后病理诊断结果的符合率高,临床价值值得肯定。

Objective To research the clinical significance of pathological tissue materials drawing and production in diagnosis of early cervical carcinoma and precancerosis. Methods 100 cases of patients whose thinprep cytology test?results were high grade squamous intraepithelial lesions in the general survey of cervical cancer in our hospital from January 2011 to January 2016 were convenient selected as the research objects, the pathological tissues provided by the traditional materials drawing and traditional embedding were used as the control group, the pathological tissues produced by the localized biopsy and cervical tissue mucous layer downward directional embedding were used as the observation group, and the postoperative pathological diagnosis results were used as the golden criterion, and the cervical biopsy results of patients were compared and analyzed. Results 38 cases of patients with cervical intraepithelial neoplasia II patients were tested in the 100 cases, and 51 cases of patients with cervical intraepithelial neoplasia III patients were tested by taking the postoperative pathological diagnosis results as the golden criterion, and 7 cases of patients with micro-infiltrating carcinoma were tested and the total test rate was 96.00%(96/100), and the coincidence rate of pathological tissue diagnosis results and postoperative pathological diagnosis results in the observation group was 93.75%(90/96), which was obviously higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion The effect of pathological tissues produced by the localized biopsy and cervical tissue mucous layer downward directional embedding is definite, and the test positive rate is high, and the coincidence rate with postoperative pathological diagnosis results is high and the clinical value is worth recognition.