NT-proBNP对妊娠高血压疾病孕妇心脏功能的评价

Evaluation of NT-proBNP on Cardiac Function in Pregnant Women with Pregnancy Induced Hypertension

目的探讨NT-proBNP评价妊娠高血压疾病孕妇心功能的临床效果。方法方便选取2015年5月—2017年5月该院收治的136例妊娠高血压疾病孕妇为研究对象,依疾病类别不同分为实验1组(妊娠期高血压,42例)、实验2组(子痫前期,55例)、实验3组(子痫,39例),另择取同期该院45名健康孕妇为对照组。全部患者均于终止妊娠前检测血清NT-proBNP水平和心肌酶指标,对比观察各组心功能分级。结果实验3组NT-proBNP(796.5±63.1)pg/mL,肌酸激酶同工酶(78.3±19.2)ng/mL,肌红蛋白(65.5±2.4)ng/mL,心功能Ⅲ~Ⅳ级97.5%,各项指标均高于对照组和实验1、2组。结论血清NT-proBNP会随着妊高症病情和心脏损害的加重而升高,可作为评价妊娠高血压疾病孕妇心功能水平的敏感指标在临床推广使用。

Objective This p a p e r tries to ev a lu a te th e c l in ic a l effect of N T -p roB N P on c a rd ia c function in p reg n an t women with pregnancy induced hyper tens ion. Methods C onvenient s ele ct ion 136 cases of h yp er ten s iv e diso rd ers comp lic at in g pregnancy women from May 2015 to May 2017 in this hospi tal were selected as the research objects, according to the dif-ferent categories of diseases, these pat ients were divided into the experimental group one（ges tat ional hyper tens ion, 42 cases）, group two （preeclamps ia, 55 cases） , and the experimental group three （eclampsia, 39 cases） , another 45 cases of healthy pregnant women of the same period were selected as the control group. All pat ients were tes ted for serum NT-proBNP levels and myocardial enzymes before terminat ion of pregnancy, and the class ificat ion of cardiac function was observed in each group. Results In th e ex p erimen ta l group th re e , th e NT -p roBNP was （7 9 6.5± 63 .1 ）p g /mL , c re a t in e k in a se isoenzyme was （78.3±19.2）ng/mL, myoglobin was （65.5±2.4）ng/mL, hear t function of III耀 IV leve l was 9 7 .5% , a l l ind ex es were h ig h e r th an the control group and the experiment group one and two. Conclusion Serum N T -p roB N P may in c re a se with th e aggravation of hyper tensive disorders complicat ing pregnancy and hear t damage. It can be used as a sensit ive index to evaluate the car-diac function of pregnant women with hyper tensive disorders complicat ing pregnancy.