活血化瘀中药临床应用不良反应研究

Research on Adverse Reactions of Clinical Application of Activating Blood Circulation Herbs

目的对活血化瘀中药的不良反应的规律以及特点进行分析。方法方便选择该院自2013年6月—2017年6月采用活血化瘀中药出现不良反应的102例患者,对其临床资料进行回顾分析。结果活血化瘀类中药所指的不良反应中,血栓通药物有37例(36.27%),血塞通药物23例(22.55%),其它药物有复方丹参药物、香丹及舒血宁药物,但占比相较于血栓通、血塞通药物相对较少;具体的不良反应表现:47例患者表现为皮疹及瘙痒,占46.08%;27例患者表现为头晕、心悸及血压升高等神经系统症状,占26.47%;其它有呼吸系统症状、胃部不适及皮下出血点、溶血等,但占比与前两者对比,相对较少。结论活血化瘀类中药物有出现不良反应的可能,其原因有多种,药物本身因素较难控制,我们能做到的是在临床使用过程中应根据患者的具体情况,如年龄、过敏史等,进而减少不良反应情况。

Objective To analyze the laws and features of adverse reactions of activating blood circulation herbs. Methods The clinical data of 102 cases of patients with adverse reactions of activating blood circulation herbs in our hospital from June 2013 to June 2017 were convenient retrospectively analyzed. Results In terms of adverse reactions, xueshuantong drugs involved 37 cases（36.27%） and xuesaitong drugs involved 23 cases（22.55%）, and the other drugs were compound danshen drugs, hongdan and shuxuening drugs, relatively low; in terms of specific adverse reactions, rash and itching were in 47 cases, accounting for 46.08%, the nerve system symptoms such as headache, palpitation and increased blood pressure were in 27 cases, accounting for 26.47%, and respiration system symptoms, stomach discomfort, subcutaneous hemorrhage and hemolysis were relatively low. Conclusion The activating blood circulation herbs may lead to adverse reactions due to multiple causes, and we should conduct our treatment according to the practical conditions of patients such as age and allergic history thus reducing the adverse reactions.