曲美他嗪治疗稳定型心绞痛患者临床疗效观察

Effect of trimetazidine in the treatment of patients with stable angina pectoris

目的探讨曲美他嗪(TMZ)对稳定型心绞痛患者运动耐量、生活质量、心脏功能的影响。方法选取稳定型心绞痛患者210例,随机分为观察组和对照组各105例。两组患者均给予冠心病常规药物治疗,每周进行3~5次运动训练。在此基础上,观察组患者加服盐酸曲美他嗪片治疗,20 mg/次,3次/d;对照组患者加服谷维素片治疗,10 mg/次,3次/d。治疗8周后观察比较两组患者的运动耐量、生活质量、心脏功能改善情况。结果治疗8周后,观察组患者代谢当量和30 min步行试验最远步行距离均优于对照组(P<0.01);观察组患者心绞痛视觉模拟(VAS)评分和心绞痛发作次数均显著优于对照组(P<0.05或0.01);观察组患者EF值显著高于对照组,NYHA心功能分级评分显著低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上,应用曲美他嗪治疗稳定型劳力性心绞痛患者,能够显著增强患者的运动耐量,提高生活质量,改善心脏功能,对促进患者的心脏康复具有重要的临床意义,值得推广使用。

Objective To investigate the effect of trimetazidine（ TMZ） on exercise tolerance,quality of life and cardiac function in patients with stable angina pectoris. Methods A total of 210 patients with stable angina pectoris were randomly divided into observation group and control group,105 in each group. All the patients were given conventional drug therapy of coronary heart disease,exercise 3 ~ 5 times a week. On the basis of these,the observation group received additional treatment with Trimetazidine Dihydrochloride,The control group with additional treatment of Oryzanol Tablets. After 8 weeks of treatment,the exercise tolerance,quality of life and improvement of cardiac function were observed and compared between the two groups. Results After 8 weeks of treatment,the MET and the 30-minutes walk test of the observation group were better than those of the control group（ P〈0. 01）;The VAS score and the number of angina attacks in the observation group were better than those in the control group（ P〈0. 05 or0. 01）; The EF value of the observation group was higher than that of the control group,and the scores of NYHA were lower than that of the control group,Their differences were significant（ P〈0. 05）. Conclusion On the basis of conventional treatment,trimetazidine in the treatment of stable exertional angina pectoris can significantly increase the patients＇ exercise tolerance,improve quality of life and heart function. It has important clinical significance to promote cardiac rehabilitation. It is worthy of promotion and application.