泌尿系感染患者发生脓毒症的危险因素研究

Risk Factors of Sepsis in Patients with Urinary Tract Infection

目的探讨泌尿系感染患者发生脓毒症的危险因素。方法选取2015年6月—2017年1月于安徽省立医院全科治疗的泌尿系感染患者70例为研究对象,根据是否发生脓毒症,将患者分为脓毒症组(29例)和非脓毒症组(41例)。记录患者是否存在肾结石、糖尿病,以及血白细胞计数、C反应蛋白(CRP)、降钙素原(PCT)水平、尿白细胞检查结果。结果非脓毒症组与脓毒症组性别、血白细胞计数、尿白细胞比较,差异无统计学意义(P>0.05)。脓毒症组年龄、肾结石、糖尿病检出率、CRP、PCT水平高于非脓毒症组(P<0.05)。多因素Logistic回归分析显示,女性是泌尿系感染患者发生脓毒症的危险因素[OR=10.727,95%CI(8.157,12.015),P<0.05]。结论女性泌尿系感染患者发生脓毒症的风险增加,临床需加强重视其脓毒症的预防。

Objective To investigate the risk factors of sepsis in patients with urinary tract infection. Methods We enrolled 70 patients with urinary tract infection who received treatment in Department of General Medicine,Anhui Provincial Hospital from June 2015 to January 2017,and divided them into sepsis group（ 29 cases） and non-sepsis group（ 41 cases）based on whether they had sepsis during treatment. Prevalence of kidney stones and diabetes,levels of serum white blood cell count,C reaction protein（ CRP）,procalcitonin（ PCT） and LEU in urine were recorded. Results There were no significant differences in gender distribution,levels of white blood cell count and LEU between the non-sepsis group and sepsis group（ P〈0. 05）. Patients in the sepsis group were older,and they had higher prevalence of kidney stones and diabetes,as well as higher levels of CRP and PCT compared with those in the non-sepsis group（ P〈0. 05）. Multivariate Logistic regression analysis showed that female was the risk factor of sepsis in patients with urinary tract infection [OR = 10. 727,95% CI（ 8. 157,12. 015）,P〈0. 05 ]. Conclusion Female patients with urinary tract infection have a higher risk for sepsis than males,so more attention should be paid to the prevention of sepsis in this population.