缬沙坦联合硝苯地平控释片治疗原发性高血压的临床疗效分析

Clinical Analysis of Valsartan Combined with Nifedipine in the Treatment of Essential Hypertension

目的分析缬沙坦联合硝苯地平控释片治疗原发性高血压的临床疗效。方法选择2015年5月—2017年6月我中心收治的160例原发性高血压患者作为研究对象,采用随机信封法将其分为研究组和对照组均80例患者,对照组给予硝苯地平控释片治疗,研究组给予缬沙坦联合硝苯地平控释片治疗,对比分析两组患者的血压状况、心率、不良反应发生率、临床治疗有效率。结果研究组血压状况、心率明显低于对照组,且临床治疗有效率明显高于对照组,P<0.05;两组患者均出现头晕、面部潮红等不良反应,停药1d后不良反应均消失,再次用药后无不良反应出现,组间对比无差异,P>0.05。结论应用缬沙坦联合硝苯地平控释片治疗原发性高血压,临床疗效显著,较单用硝苯地平控释片可有效改善血压水平,同时不良反应无明显升高,安全性较高,值得临床推广应用。

Objective To analyze the clinical efficacy of valsartan combined with nifedipine in the treatment of essential hypertension. Methods From January 2015 to June 2017,160 patients with essential hypertension were enrolled in this study. Eighteen patients were divided into study group and control group by random envelope method. The control group received nitr. The treatment group was treated with valsartan combined with nifedipine controlled release tablets. The blood pressure status,heart rate,adverse reaction rate and clinical treatment efficiency of the two groups were compared and analyzed. Results The blood pressure and heart rate of the study group were significantly lower than those of the control group,and the effective rate of clinical treatment was significantly higher than that of the control group（ P〈 0. 05）. Adverse reactions such as dizziness and facial flushing occurred in the two groups. No adverse reactions occurred after treatment,no difference between groups（ P 〉0. 05）. Conclusion The treatment of primary hypertension with valsartan combined with nifedipine is effective in the treatment of essential hypertension. It can effectively improve the blood pressure level,and has less adverse reaction and high safety. It is worthy of clinical application.