野山杏总黄酮抗急性炎症作用研究

Study on Anti-acute Inflammatory Effect of Total Falconoids fromArmeniaca sibirica(L.)Lam.

研究野山杏[Armeniaca sibirica(L.)Lam.]总黄酮对小鼠的抗急性炎症作用。采用冰醋酸致小白鼠腹腔毛细血管通透性增加、蛋清致小白鼠足跖肿胀、二甲苯致小鼠耳廓肿胀等方法研究野山杏总黄酮对急性炎症的抑制作用。毛细血管通透性增加实验中,野山杏总黄酮各剂量组的OD值与空白对照组相比极显著降低(P<0.01);野山杏总黄酮各剂量组0.5~3.0h足趾肿胀度与空白对照组相比极显著减小(P<0.01);野山杏总黄酮各剂量组小鼠耳肿胀度与空白对照组相比极显著下降(P<0.01)。野山杏总黄酮对肿胀反应和毛细血管通透性增加有显著的抑制作用,对肿胀和渗出等局部急性炎症有一定的抑制作用。

To study the effect of total falconoids from Armeniaca sibirica(L.)Lam.on acute inflammation in mice.The inhibition effect of total falconoids on acute inflammation was studied by the method of increasing capillary permeability in mice induced by glacial acetic acid,foot metatarsus swelling induced by egg white and the ear edema induced by xylene in mice.In the experiment of increasing blood capillary permeability,there existed a significant difference between the OD value of every total falconoid groups and the blank control group(P <0.01).Similarly,the toe swelling degree of total flavonoids group showed significant difference compared with the blank control group at 0.5-3.0 h(P <0.01).Compared with the blank control group,the ear swelling degree of the total flavonoids in each dose group was significantly different(P <0.01).Armeniaca sibirica(L.)Lam.flavonoids has significant inhibitory effect on swelling reaction and capillary permeability,and has apparent inhibitory effect on the swelling and exudation of local acute inflammation.