肝细胞生长因子及其受体在新药发现中的研究进展

Progress in researches of hepatocyte growth factor and its receptor for new drug development

肝细胞生长因子(hepatocyte growth factor,HGF)及其受体(Met)在组织的发育、再生和体内平衡中发挥着重要的作用,该信号通路传导异常可以正负双向调节多种疾病的发生和发展。目前,基于HGF/Met通路在生理和病理上的重要作用,HGF及其受体Met已成为新药发现的重要靶点,如在肿瘤的治疗中选择性的Met抑制剂是靶向治疗的热点,在心脑血管疾病中HGF类似物或者Met激活剂的研究也进展较快。本文主要对HGF及其受体Met在肿瘤和心脑血管疾病治疗领域的研究进展进行综述。

Hepatocyte growth factor （HGF） plays significant roles in the development,regeneration and homeostasis of tissues,so do their receptors （Met）.Abettant regulation of the growth factor signaling participates in almost every stage （from the onset and progression） of diseases and pathology in both positive and negative directions.Based on the important physiological and pathological roles of hepatocyte growth factor and their receptors,both HGF and Met have become the targets in drug discovery,for instance,selective inhibitors against hepatocyte growth factors and their growth factor receptors,are currently indispensable in the molecular targeted therapy of malignant tumors.On the other hand,in the cardiovascular system,HGF imitations and Met activators also made a lot progress in research and development of drugs.The progress of HGF and Met in malignant tumors and cardiovascular diseases was described in this article.