血浆低密度脂蛋白和高密度脂蛋白亚组分的临床意义及检测研究进展

Advances in clinical significance and detection research of plasma low density lipoprotein and high density lipoprotein subunits

血浆低密度脂蛋白(LDL)和高密度脂蛋白(HDL)是临床心血管疾病(CVD)的重要生物化学指标。一些脂代谢异常疾病如肥胖、糖尿病、高血压和高脂血症尤其是动脉粥样硬化等都是CVD的危险因素,许多新的研究证明这些疾病患者的血浆LDL和HDL亚组分存在异常,其临床意义大于LDL和HDL总体异常。血浆LDL和HDL异常亚组分作为CVD临床检测指标已引起了广泛研究与关注。本文旨在对血浆LDL和HDL亚组分的临床意义及检测研究进展加以论述。

Plasma low density lipoprotein （LDL） and high density lipoprotein （HDL） are important biochemical indicators of clinical cardiovascular disease （CVD）. Some disorders of lipid metabolism, such as obesity, diabetes melli- tus, hypertension and hyperlipidemia, especially atherosclerosis, are risk factors for CVD. Many new studies have demon- strated abnormalities of plasma LDL and HDL subunits in patients with these diseases, and their clinical significance is greater than the overall abnormalities of LDL and I4DL. Abnormal subunits of plasma LDL and HDL have been extensively studied and paid attention to as a clinical indicator of CVD. The purpose of this paper is to discuss the advances in clinical significance and detection research of plasma LDL and HDL subunits.