炎症相关microRNA与血管钙化

Inflammation-related microRNA and vascular calcification

血管钙化指钙磷在血管壁的异位沉积,常见于糖尿病、动脉粥样硬化、慢性肾脏病等慢性炎症疾病,与心血管疾病的发病率和病死率密切相关。血管钙化作为一种慢性炎症状态,炎症因子在其中具有重要调控作用。作为一种非编码小RNA的microRNA,许多研究证实其可以通过调控血管平滑肌细胞的表型转换、钙磷稳态、局部及系统炎症因子表达等来引起血管钙化的发生发展。目前发现的microRNA种类较多,本文对炎症与血管钙化的关系以及炎症相关microRNA如何通过调控炎症因子表达影响血管钙化过程进行综述,希望能为进一步探究血管钙化机制及临床预防、治疗血管钙化提供新思路。

It is known that vascular calcification is a regulated ectopic mineral deposition, which is a common char- acteristic of chronic inflammatory disorders, such as type 2 diabetes mellitus, atherosclerosis, and chronic kidney disease. Vascular calcification is closely related to the morbidity and mortality of cardiovascular diseases. Vascular calcification is as a state of chronic inflammatory disorders, and inflammatory factors may play an important role in the regulation of vascu- lar calcification. As a kind of non-encoding small RNA, microRNA, many studies have confirmed that it can be through the regulation of vascular smooth muscle cell phenotype conversion, calcium and phosphorus homeostasis, local and system- ic expression of inflammatory factors to cause the occurrence and development of vascular calcification. Recently, various kinds of microRNA have been found. In this review, the focus will be on the relationship between inflammation and vascu- lar calcification, the role of inflammation-related microRNA in vascular calcification by regulating the expression of inflam- matory factors, which will provide novel concept for future studies on mechanisms of vascular calcification, prevention and treatment strategies of vascular calcification in clinic.